Clinical Radiology
Volume 65, Issue 9 , Pages 720-728 , September 2010

A retrospective analysis of selective internal radiation therapy (SIRT) with yttrium-90 microspheres in patients with unresectable hepatic malignancies

  • A. Omed

      Affiliations

    • Manchester Medical School, University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK
    • Corresponding Author InformationGuarantor and correspondent: A. Omed, 155 Manchester Road, Chorlton-Cum-Hardy, Manchester M16 OFE, UK. Tel.: +44 7888714797.
    • ,
  • J.A.L. Lawrance

      Affiliations

    • Radiology Department, The Christie NHS Foundation Trust, Wilmslow Road, Manchester, M20 4BX, UK
    • ,
  • G. Murphy

      Affiliations

    • Radiology Department, Manchester Royal Infirmary, Oxford Road, Manchester, M13, 9WL, UK
    • ,
  • H.-U. Laasch

      Affiliations

    • Radiology Department, The Christie NHS Foundation Trust, Wilmslow Road, Manchester, M20 4BX, UK
    • ,
  • G. Wilson

      Affiliations

    • Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester, M20 4BX, UK
    • ,
  • T. Illidge

      Affiliations

    • Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester, M20 4BX, UK
    • ,
  • J. Tipping

      Affiliations

    • Nuclear Medicine, The Christie NHS Foundation Trust, Wilmslow Road, Manchester, M20 4BX, UK
    • ,
  • M. Zivanovic

      Affiliations

    • Nuclear Medicine, The Christie NHS Foundation Trust, Wilmslow Road, Manchester, M20 4BX, UK
    • ,
  • S. Jeans

      Affiliations

    • Radiology Department, Manchester Royal Infirmary, Oxford Road, Manchester, M13, 9WL, UK

Received 26 October 2009 ,Revised 14 March 2010 ,Accepted 7 May 2010.

References 

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  3. Wickremesekera JK, Chen W, Cannan RJ, et al. Serum proinflammatory cytokine response in patients with advanced liver tumors following selective internal radiation therapy (SIRT) with 90-yttrium microspheres. Int J Radiat Oncol Biol Phys. 2001;49:1015–1021
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  8. Kennedy AS, Dezarn WA, Mcneillie P. 90Y microspheres: concepts and principles. In:  Bilbao JI,  Reiser MF editor. Liver radioembolisation with 90Y microspheres. Berlin: Springer-Verlag; 2008;p. 1–9
  9. Lim L, Gibbs P, Yip D, et al. A prospective evaluation of treatment with selective internal radiation therapy (SIR-spheres) in patients with unresectable liver metastases from colorectal cancer previously treated with 5-FU based chemotherapy. BMC Cancer. 2005;5:132
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  12. Hoffmann RT, Bilbao JI, Jakobs TF, et al. Complications and side-effects. In:  Bilbao JI,  Reiser MF editor. Radioembolisation with 90Y microspheres. Berlin: Springer-Verlag; 2008;p. 139–146
  13. Leung TWT, Lau W-Y, Ho SKW, et al. Radiation pneumonitis after selective internal radiation treatment with intraarterial 90-yttrium-microspheres for inoperable hepatic tumors. Int J Radiat Oncol Biol Phys. 1995;33:919–924
  14. Van Hazel G, Blackwell A, Anderson J, et al. Randomised phase 2 trial of SIR-spheres® plus fluorouracil/leucovorin chemotherapy versus fluorouracil/leucovorin chemotherapy alone in advanced colorectal cancer. J Surg Oncol. 2004;88:78–85
  15. Gray B, Van Hazel G, Hope M, et al. Randomised trial of SIR-Spheres plus chemotherapy vs. chemotherapy alone for treating patients with liver metastases from primary large bowel cancer. Ann Oncol. 2001;12:1711–1720
  16. Sharma RA, Van Hazel GA, Morgan B, et al. Radioembolization of liver metastases from colorectal cancer using yttrium-90 microspheres with concomitant systemic oxaliplatin, fluorouracil, and leucovorin chemotherapy. J Clin Oncol. 2007;25:1099–1106
  17. Stubbs R, Cannan R, Mitchell A. Selective internal radiation therapy with 90yttrium microspheres for extensive colorectal liver metastases. J Gastrointest Surg. 2001;5:294–302
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  19. Andrews JC, Walker SC, Ackermann RJ, et al. Hepatic radioembolization with yttrium-90 containing glass microspheres: preliminary results and clinical follow-up. J Nucl Med. 1994;35:1637–1644
  20. Grady E. Internal radiation therapy of hepatic cancer. Dis Colon Rectum. 1979;22:371–375
  21. Jakobs TF. Radiologic detection and assessment of tumour response. In:  Bilbao JI,  Reiser MF editor. Liver radioembolisation with 90Y microspheres. Berlin: Springer-Verlag; 2008;p. 93–106
  22. Boppudi S, Wickremesekera S, Nowitz M, Stubbs RS. Evaluation of the role of CT in the assessment of response to selective internal radiation therapy in patients with colorectal liver metastases. Australas Radiol. 2006;50:570–577

PII: S0009-9260(10)00194-7

doi: 10.1016/j.crad.2010.05.001

Clinical Radiology
Volume 65, Issue 9 , Pages 720-728 , September 2010

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