Clinical Radiology
Volume 65, Issue 9 , Pages 701-707 , September 2010

Characterization of liver metastases: the efficacy of biphasic magnetic resonance imaging with ferucarbotran-enhancement

  • H.S. Hong

      Affiliations

    • Department of Radiology, Hallym University College of Medicine, Kangnam Sacred Heart Hospital, Seoul, Republic of Korea
    • ,
  • J.H. Byun

      Affiliations

    • Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    • ,
  • H.J. Won

      Affiliations

    • Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    • ,
  • K.W. Kim

      Affiliations

    • Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    • ,
  • S.S. Lee

      Affiliations

    • Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    • ,
  • M.G. Lee

      Affiliations

    • Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    • Corresponding Author InformationGuarantor and correspondent: M.G. Lee, Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 388–1, Pungnap-2dong, Songpa-gu, Seoul, 138–736, Republic of Korea. Tel.: +82 2 3010 4400; fax: +82 2 476 0090.
    • ,
  • S.C. Yun

      Affiliations

    • Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

Received 6 September 2009 ,Revised 19 April 2010 ,Accepted 25 April 2010.

References 

  1. Reimer P, Jahnke N, Fiebich M, et al. Hepatic lesion detection and characterization: value of nonenhanced MR imaging, superparamagnetic iron oxide-enhanced MR imaging, and spiral CT-ROC analysis. Radiology. 2000;217:152–158
  2. Vogl TJ, Schwarz W, Blume S, et al. Preoperative evaluation of malignant liver tumors: comparison of unenhanced and SPIO (Resovist)-enhanced MR imaging with biphasic CTAP and intraoperative US. Eur Radiol. 2003;13:262–272
  3. Pirovano G, Vanzulli A, Marti-Bonmati L, et al. Evaluation of the accuracy of gadobenate dimeglumine-enhanced MR imaging in the detection and characterization of focal liver lesions. AJR Am J Roentgenol. 2000;175:1111–1120
  4. Kim YK, Lee JM, Kim CS. Gadobenate dimeglumine-enhanced liver MR imaging: value of dynamic and delayed imaging for the characterization and detection of focal liver lesions. Eur Radiol. 2004;14:5–13
  5. Reimer P, Balzer T. Ferucarbotran (Resovist): a new clinically approved RES-specific contrast agent for contrast-enhanced MRI of the liver: properties, clinical development, and applications. Eur Radiol. 2003;13:1266–1276
  6. Seneterre E, Taourel P, Bouvier Y, et al. Detection of hepatic metastases: ferumoxides-enhanced MR imaging versus unenhanced MR imaging and CT during arterial portography. Radiology. 1996;200:785–792
  7. Ba-Ssalamah A, Heinz-Peer G, Schima W, et al. Detection of focal hepatic lesions: comparison of unenhanced and SHU 555 A-enhanced MR imaging versus biphasic helical CTAP. J Magn Reson Imaging. 2000;11:665–672
  8. Ward J, Guthrie JA, Wilson D, et al. Colorectal hepatic metastases: detection with SPIO-enhanced breath-hold MR imaging-comparison of optimized sequences. Radiology. 2003;228:709–718
  9. Mergo PJ, Helmberger T, Nicolas AI, Ros PR. Ring enhancement in ultrasmall superparamagnetic iron oxide MR imaging: a potential new sign for characterization of liver lesions. AJR Am J Roentgenol. 1996;166:379–384
  10. Takahama K, Amano Y, Hayashi H, Ishihara M, Kumazaki T. Detection and characterization of focal liver lesions using superparamagnetic iron oxide-enhanced magnetic resonance imaging: comparison between ferumoxides-enhanced T1-weighted imaging and delayed-phase gadolinium-enhanced T1-weighted imaging. Abdom Imaging. 2003;28:525–530
  11. Higashihara H, Murakami H, Kim T, et al. Differential diagnosis between metastatic tumors and nonsolid benign lesions of the liver using ferucarbotran-enhanced MR imaging. Eur J Radiol. 2010;73:125–130
  12. Lutz AM, Willmann JK, Goepfert K, Marincek B, Weishaupt D. Hepatocellular carcinoma in cirrhosis: enhancement patterns at dynamic gadolinium- and superparamagnetic iron oxide-enhanced T1-weighted MR imaging. Radiology. 2005;237:520–528
  13. Park Y, Choi D, Kim SH, et al. Changes in signal-to-noise ratios and contrast-to-noise ratios of hypervascular hepatocellular carcinomas on ferucarbotran-enhanced dynamic MR imaging. Eur J Radiol. 2006;59:424–431
  14. Chou CT, Chen RC, Chen WT, Lii JM. Detection of hepatocellular carcinoma by ferucarbotran-enhanced magnetic resonance imaging: the efficacy of accumulation phase fat-suppressed T1-weighted imaging. Clin Radiol. 2009;64:22–29
  15. Imai Y, Murakami T, Yoshida S, et al. Superparamagnetic iron oxide-enhanced magnetic resonance images of hepatocellular carcinoma: correlation with histological grading. Hepatology. 2000;32:205–212
  16. Tanimoto A, Wakabayashi G, Shinmoto H, Okuda S, Kuribayashi S, Mukai M. The mechanism of ring enhancement in hepatocellular carcinoma on superparamagnetic iron oxide-enhanced T1-weighted images: an investigation into peritumoral Kupffer cells. J Magn Reson Imaging. 2005;21:230–236
  17. Reimer P, Muller M, Marx C, et al. T1 effects of a bolus-injectable superparamagnetic iron oxide, SH U 555 A: dependence on field strength and plasma concentration—preliminary clinical experience with dynamic T1-weighted MR imaging. Radiology. 1998;209:831–836
  18. Hamm B, Thoeni RF, Gould RG, et al. Focal liver lesions: characterization with nonenhanced and dynamic contrast material-enhanced MR imaging. Radiology. 1994;190:417–423
  19. Morana G, Grazioli L, Testoni M, Caccia P, Procacci C. Contrast agents for hepatic magnetic resonance imaging. Top Magn Reson Imaging. 2002;13:117–150
  20. Kanematsu M, Matsuo M, Yamada Y, et al. Perilesional hyperintense rim of malignant hepatic tumors on ferumoxide-enhanced T1-weighted gradient-echo MR images: correlation between MR imaging and histopathologic findings. J Magn Reson Imaging. 2003;18:40–48

PII: S0009-9260(10)00191-1

doi: 10.1016/j.crad.2010.04.011

Clinical Radiology
Volume 65, Issue 9 , Pages 701-707 , September 2010

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