Clinical Radiology
Volume 65, Issue 7 , Pages 517-521, July 2010

The biology underlying molecular imaging in oncology: from genome to anatome and back again

H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33602, USA

Received 15 December 2009; received in revised form 23 April 2010; accepted 30 April 2010.

Cancers are complex, evolving, multiscale ecosystems that are characterized by profound spatial and temporal heterogeneity. The interactions in cancer are non-linear in that small changes in one variable can have large changes on another. These multiple interacting phenotypes and spatial scales can best be understood with appropriate mathematical and computational models. Imaging is central to this investigation because it can non-destructively and longitudinally characterize spatial variations in the tumour phenotype and environment so that the system dynamics over time can be captured quantitatively.

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PII: S0009-9260(10)00182-0

doi:10.1016/j.crad.2010.04.005

Clinical Radiology
Volume 65, Issue 7 , Pages 517-521, July 2010

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