Clinical Radiology
Volume 65, Issue 8 , Pages 593-600 , August 2010

Classical and unusual imaging appearances of melorheostosis

  • S. Suresh

      Affiliations

    • Department of Clinical Radiology, Plymouth Hospitals NHS Trust, Plymouth, UK
    • Corresponding Author InformationGuarantor and correspondent: S. Suresh, Department of Clinical Radiology, Plymouth Hospitals NHS Trust, Derriford Road, Plymouth PL6 8DH, UK. Tel.: +44 1752763247.
  • ,
  • T. Muthukumar

      Affiliations

    • Department of Radiology, The Royal National Orthopaedic Hospital NHS Trust and The London Bone and Soft Tissue Tumour Service, Stanmore, UK
  • ,
  • A. Saifuddin

      Affiliations

    • Department of Radiology, The Royal National Orthopaedic Hospital NHS Trust and The London Bone and Soft Tissue Tumour Service, Stanmore, UK

Received 30 August 2009 ,Revised 2 February 2010 ,Accepted 9 February 2010.

References 

  1. Taybi H, Lachman RS. Radiology of syndromes, metabolic disorders, and skeletal dysplasias. (4th ed.). Chicago: Year Book; 1996;p. 843–4
  2. Kalbermatten NT, Vock P, Rufenacht D, et al. Progressive melorheostosis in the peripheral and axial skeleton with associated vascular malformations: imaging findings over three decades. Skeletal Radiol. 2001;30:48–52
  3. Brown RR, Steiner GC, Lehman WB. Melorheostosis: case report with radiologic–pathologic correlation. Skeletal Radiol. 2000;29:548–552
  4. Soffa DJ, Sire DJ, Dodson JH. Melorheostosis with linear scleroderma skin changes. Radiology. 1975;114:577–578
  5. Gold RH, Mirra JM. Case report 35. Melorheostosis. Skeletal Radiol. 1977;2:57–58
  6. Connor JM. Soft tissue ossification. Berlin: Springer-Verlag; 1983;102–103
  7. Dissing I, Zafirovski G. Para-articular ossifications associated with melorheostosis leri. Acta Orthop Scand. 1979;50:717–719
  8. Goldman AB, Schneider R, Huvos AS, et al. Case report 778. Melorheostosis presenting as two soft-tissue masses with osseous changes limited to the axial skeleton. Skeletal Radiol. 1993;22:206–210
  9. Pajarinen P, Alhava E, Rehnberg V. Melorheostosis. A case report with special reference to bone mineral density, bone circulation and bone scan. Ann Chir Gynaecol. 1978;67:36–37
  10. Yu JS, Resnick D, Vaughan LM, et al. Melorheostosis with an ossified soft tissue mass: MR features. Skeletal Radiol. 1995;24:367–370
  11. Leri A, Joanny J. Une affection non decrite des os. Hyperostose ‘encoulee’ sur toute la longeur d'un member ou ‘melorheostose’. Bull Mem Soc Med Hop Paris. 1922;46:1141
  12. Kelley MA, Lytle K. Brief communication: a possible case of melorheostosis from antiquity. Am J Phys Anthropol. 1995;98:369–374
  13. Zimmer P. Bietrage zur klinischen. Chirurgie. 1927;140:75
  14. Putty V. L'Osteosi eburneizzante monomelica (una nuova syndrome osteopatica). Chir organi. 1927;11:335
  15. Moore JJ, de Lorimier AA. Melorheostosis leri — review of literature and report of a case. AJR Am J Roentgenol. 1933;29:161–171
  16. Lassere C. A case of melorheostosis. [in French] Rev Rhum Mal Osteoartic. 1960;27:347
  17. Campbell CJ, Papademetriou T, Bonfiglio M. Melorheostosis. A report of the clinical, roentgenographic, and pathological findings in fourteen cases. J Bone Joint Surg Am. 1968;50:1281–1304
  18. Murray RO, McCredie J. Melorheostosis and the sclerotomes: a radiological correlation. Skeletal Radiol. 1979;4:57–71
  19. Inman VT, Saunders JBde C. Referred pain from skeletal structures. J Nerv Ment Dis. 1944;99:660
  20. Fryns JP. Melorheostosis and somatic mosaicism. Am J Med Genet. 1995;28:199
  21. Butkus CE, Michels VV, Lindor NM, et al. Melorheostosis in a patient with familial osteopoikilosis. Am J Med Genet. 1997;72:43–46
  22. Nevin NC, Thomas PS, Davis RI, et al. Melorheostosis in a family with autosomal dominant osteopoikilosis. Am J Med Genet. 1999;82:409–414
  23. Debeer P, Pykels E, Lammens J, et al. Melorheostosis in a family with autosomal dominant osteopoikilosis: report of a third family. Am J Med Genet. 2003;119A:188–193
  24. Happle R. Segmental forms of autosomal dominant skin disorders: different types of severity reflect different states of zygosity. Am J Med Genet. 1996;66:241–242
  25. Happle R. Melorheostosis may originate as a type 2 segmental manifestation of osteopoikilosis. Am J Med Genet. 2004;125A:221–223
  26. Hellemans J, Preobrazhenska O, Willaert A. Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke–Ollendorff syndrome and melorheostosis. Nat Genet. 2004;36:1213–1218
  27. Hellemans J, Debeer P, Wright M, et al. Germline LEMD3. Hum Mutat. 2006;27:290
  28. Mumm S, Wenkert D, Zhang X, et al. Deactivating germline mutations in LEMD3 cause osteopoikilosis and Buschke–Ollendorff syndrome, but not sporadic melorheostosis. J Bone Miner Res. 2007;22:243–250
  29. Couto AR, Bruges-Armas J, Peach CA, et al. A novel LEMD3 mutation common to patients with osteopoikilosis with and without melorheostosis. Calcif Tissue Int. 2007;81:81–84
  30. Khurana JS, Ehara S, Rosenberg AE, et al. Melorheostosis of ilium, femur, and adjacent soft tissues. Skeletal Radiol. 1988;17:53
  31. Baer SC, Ayala AG, Ro JY, et al. Case report 843. Skeletal Radiol. 1994;23:310–314
  32. Siegel A, Williams H. Linear scleroderma and melorheostosis. Br J Radiol. 1992;65:266–268
  33. Judkiewicz AM, Murphey MD, Resnik CS, et al. Advanced imaging of melorheostosis with emphasis on MRI. Skeletal Radiol. 2001;30:447–453
  34. McCarthy M, Mehdian H, Fairbairn KJ, et al. Melorheostosis of the tenth and eleventh thoracic vertebrae crossing the facet joint: a rare cause of back pain. Skeletal Radiol. 2004;33:283–286
  35. Garver P, Resnick D, Haghighi P, et al. Melorheostosis of the axial skeleton with associated fibrolipomatous lesions. Skeletal Radiol. 1982;9:41–44
  36. Greenspan A, Azouz EM. Bone dysplasia series: melorheostosis: review and update. Can Assoc Radiol J. 1999;50:324–330
  37. Greenspan A. Sclerosing bone dysplasias—a target-site approach. Skeletal Radiol. 1991;20:561–583
  38. Morris JM, Samilson RL, Corley CL. Melorheostosis: review of the literature and report of an interesting case with a nineteen-year follow-up. J Bone Joint Surg Am. 1963;45:1191–1206
  39. De Goede E, Fagard R, Fryns JP. Unique cause of renovascular hypertension: melorheostosis associated with a malformation of the renal arteries. J Hum Hypertens. 1996;10:57–59
  40. Ingen-Housz-Oro S, Chigot V, Hamel-Teillac D, et al. Melorheostosis associated with arteriovenous malformation of the ear. Ann Dermatol Venereol. 2001;128:915–918
  41. Hall R. A case report melorheostosis with cutaneous haemangioma and lymphatic vesicles. J Bone Joint Surg Br. 1961;43:335–337
  42. Patrick JH. Melorheostosis associated with arteriovenous aneurysm of the left arm and trunk: report of a case with long follow-up. J Bone Joint Surg Br. 1969;51:126–129
  43. Ewald FC. Unilateral mixed sclerosing bone dystrophy associated with unilateral lymphangiectasis and capillary hemangioma: a case report. J Bone Joint Surg Am. 1972;54:878–880
  44. Taylor DR. A case of melorheostosis with associated linear cutaneous vascular malformation. Clin Exp Dermatol. 1981;6:47–51
  45. Kessler HB, Recht MP, Dalinka MK. Vascular anomalies in association with osteodystrophies — a spectrum. Skeletal Radiol. 1983;10:95–101
  46. Applebaum RE, Caniano DA, Sun CC, et al. Synchronous left subclavian and axillary artery aneurysms associated with melorheostosis. Surgery. 1986;99:249–253
  47. Murray RO. Melorheostosis associated with congenital arteriovenous aneurysm. Proc R Soc Med. 1951;44:473–475
  48. Roger D, Bonnetblanc JM, Leroux-Robert C. Melorheostosis with associated minimal change nephrotic syndrome, mesenteric fibromatosis and capillary haemangiomas. Dermatology. 1994;188:166–168
  49. Tinschert S, Stein A, Göldner B, et al. Melorheostosis with ipsilateral nevus sebaceus (didymosis melorheosebacea). Eur J Dermatol. 2003;13:21–24
  50. Iglesias JH, Stocks AL, Pena DR, et al. Renal artery stenosis associated with melorheostosis. Pediatr Nephrol. 1994;8:441–443
  51. Ishibe M, Inoue M, Saitou K. Melorheostosis with occlusion of dorsalis pedis artery. Arch Orthop Trauma Surg. 2002;22:56–57
  52. Murphy M, Kearns S, Cavanagh M, et al. Occurrence of osteosarcoma in a melorheostotic femur. Ir Med J. 2003;96:55–56
  53. Brennan DD, Bruzzi JF, Thakore H, et al. Osteosarcoma arising in a femur with melorheostosis and osteopathia striata. Skeletal Radiol. 2002;31:471–474
  54. Böstman OM, Holmström T, Riska EB. Osteosarcoma arising in a melorheostotic femur. A case report. J Bone Joint Surg Am. 1987;69:1232–1237
  55. Baer SC, Ayala AG, Ro JY, et al. Case report 843. Malignant fibrous histiocytoma of the femur arising in melorheostosis. Skeletal Radiol. 1994;23:310–314
  56. Raby N, Vivian G. Case report 478. Melorrheostosis of the axial skeleton with associated intrathecal lipoma. Skeletal Radiol. 1988;17:216–219
  57. Ippolito V, Mirra JM, Motta C, et al. Melorheostosis in association with desmoid tumor. Skeletal Radiol. 1993;22:284–288
  58. Rhys R, Davies AM, Mangham DC, et al. Sclerotome distribution of melorheostosis and multicentric fibromatosis. Skeletal Radiol. 1998;27:633–636
  59. Reznik M, Fried G. Myelopathy associated with melorheostosis: a case report. Arch Phys Med Rehab. 2005;86:1495–1497
  60. Lee SH, Sanderson J. Hypophosphataemic rickets and melorheostosis. Clin Radiol. 1989;40:209–211
  61. Sweriduk ST, DeLuca SA. Melorheostosis. Am Fam Physician. 1986;34:113–114
  62. McLeod RA, Beabout JW, Cooper KL, et al. Case of the day. AJR Am J Roentgenol. 1984;142:1062–1068
  63. Robertson PA, Don AS, Miller MV. Painful lumbosacral melorheostosis treated by fusion. Spine. 2003;28:E234–E238
  64. Williams JW, Monaghan D, Barrington NA. Cranio-facial melorheostosis: case report and review of the literature. Br J Radiol. 1991;64:60–62
  65. Lievre JA, Dechaume M, Crepy C, et al. Cranio-facial melorheostosis. Rev Rhum Mal Osteoartic. 1959;26:785–792
  66. Caroli A, Dourov N, van den Eynde H, et al. Craniofacial melorheostosis. Report of a case and review of the literature, Rev Stomatol Chir Maxillofac. 1987;88:40–47
  67. Freyschmidt J. Melorheostosis: a review of 23 cases. Eur Radiol. 2001;11:474–479
  68. Parikh J, Hyare H, Saifuddin A. The imaging features of post-traumatic myositis ossificans, with emphasis on MRI. Clin Radiol. 2002;57:1058–1066
  69. Drane WE. Detection of melorheostosis on bone scan. Clin Nucl Med. 1987;12:548–551
  70. Davis DC, Syklawer R, Cole RL. Melorheostosis on three-phase bone scintigraphy. Clin Nucl Med. 1992;17:561–564
  71. Mahoney J, Achong DM. Demonstration of increased bone metabolism in melorheostosis by multiphase bone scanning. Clin Nucl Med. 1991;16:847–848
  72. Gong HS, Lee KH, Oh JH, et al. Successful elbow contracture release secondary to melorheostosis a case report. J Bone Joint Surg Am. 2008;90:1106–1111

PII: S0009-9260(10)00099-1

doi: 10.1016/j.crad.2010.02.004

Clinical Radiology
Volume 65, Issue 8 , Pages 593-600 , August 2010