Clinical Radiology
Volume 65, Issue 6 , Pages 431-439, June 2010

Imaging manifestations of progressive multifocal leukoencephalopathy

  • R. Shah
    • ,
  • A.K. Bag

      Affiliations

    • Corresponding Author InformationGuarantor and correspondent: A. K. Bag, Division of Neuroradiology, Department of Radiology, 619 19th St S, WP-150, Birmingham, AL-35249-6830, USA. Tel.: +1 205 934 3920; fax: +1 205 975 9262.
    • ,
  • P.R. Chapman
    • ,
  • J.K. Curé

Division of Neuroradiology, Department of Diagnostic Radiology, University of Alabama at Birmingham, Birmingham, Alabama, USA

Received 25 November 2009; received in revised form 23 February 2010; accepted 2 March 2010. published online 20 April 2010.

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease caused by reactivation of JC virus in immunosuppressed patients. The diagnosis is usually suggested on imaging and confirmed by cerebrospinal fluid polymerase chain reaction (PCR) for JC virus DNA. In this article, we review the imaging manifestations of PML on computed tomography (CT), magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), diffusion tensor imaging (DTI), MR spectroscopy, single photon-emission computed tomography (SPECT) and positron-emission tomography (PET), and outline the role of imaging in follow-up and prognostication.

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PII: S0009-9260(10)00095-4

doi:10.1016/j.crad.2010.03.001

Clinical Radiology
Volume 65, Issue 6 , Pages 431-439, June 2010

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