Follicular non-Hodgkin's lymphoma

Hayashi, D.; Lee, J.C.; Devenney-Cakir, B.; Zaim, S.; Ounadjela, S.; Solal-Céligny, P.; Juweid, M.; Guermazi, A.

doi:10.1016/j.crad.2010.01.010

« Previous Next »Clinical Radiology
Volume 65, Issue 5 , Pages 408-420, May 2010

Follicular non-Hodgkin's lymphoma

D. Hayashi
- Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA 02118, USA
- Guarantor and correspondent: D. Hayashi, Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA 02118, USA. Tel.: +1 617 414 4957; fax: +1 617 638 6616.
J.C. Lee
- Department of Pathology, Boston University School of Medicine, Boston, MA 02118, USA
B. Devenney-Cakir
- Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA 02118, USA
S. Zaim
- Department of Radiology Services, Synarc Inc., San Francisco, CA, USA
S. Ounadjela
- Department of Radiology Services, Synarc Inc., San Francisco, CA, USA
P. Solal-Céligny
- Department of Hematology, Centre Jean Bernard, Le Mans, France
M. Juweid
- Department of Radiology, University of Iowa, Iowa City, IA, USA
A. Guermazi
- Department of Radiology, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA 02118, USA

Received 24 November 2009; received in revised form 6 January 2010; accepted 8 January 2010. published online 05 April 2010.

Follicular non-Hodgkin's lymphoma (NHL) is a unique subtype of NHL, which is indolent, incurable with a high prevalence of residual mass after treatment, and may transform to more aggressive NHL. The aim of this review is to (1) describe the histological and flow cytometry characteristics of follicular NHL; (2) introduce the Follicular Lymphoma International Prognostic Index 2 (FLIPI-2), which allows better treatment selection and patient stratification for clinical trials; (3) illustrate the classic and atypical ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), and positron-emission tomography (PET)/CT appearance of follicular NHL; and (4) characterize the appearance of nodal and extranodal follicular NHL with pathological correlation. Imaging is essential in every step of the management of patients with follicular lymphoma. Overall survival is improved with better predictive tools and new targeted biological therapies. Radiologists should be aware of possible active residual mass, indolent recurrence, transformation, and association with other primary cancers in patients treated for follicular lymphoma.