Clinical Radiology
Volume 65, Issue 5 , Pages 358-365 , May 2010

Comparison of gadoxetic acid-enhanced MRI and superparamagnetic iron oxide-enhanced MRI for the detection of hepatocellular carcinoma

  • Y.K. Kim

      Affiliations

    • Department of Diagnostic Radiology, Research Institute of Clinical Medicine, Chonbuk National University Hospital and Medical School, Keum Am Dong, JeonJu, Republic of Korea
    • Corresponding Author InformationGuarantor and correspondent: Y.K. Kim, Department of Diagnostic Radiology, Chonbuk National University Hospital and Medical School, Keum Am Dong, JeonJu, Republic of Korea. Tel.: +82 63 250 2314; fax: +82 63 272 0481.
  • ,
  • C.S. Kim

      Affiliations

    • Department of Diagnostic Radiology, Research Institute of Clinical Medicine, Chonbuk National University Hospital and Medical School, Keum Am Dong, JeonJu, Republic of Korea
  • ,
  • Y.M. Han

      Affiliations

    • Department of Diagnostic Radiology, Research Institute of Clinical Medicine, Chonbuk National University Hospital and Medical School, Keum Am Dong, JeonJu, Republic of Korea
  • ,
  • G. Park

      Affiliations

    • Department of Diagnostic Radiology, Research Institute of Clinical Medicine, Chonbuk National University Hospital and Medical School, Keum Am Dong, JeonJu, Republic of Korea
  • ,
  • S.B. Hwang

      Affiliations

    • Department of Diagnostic Radiology, Research Institute of Clinical Medicine, Chonbuk National University Hospital and Medical School, Keum Am Dong, JeonJu, Republic of Korea
  • ,
  • H.C. Yu

      Affiliations

    • Department of General Surgery, Chonbuk National University Hospital and Medical School, Keum Am Dong, JeonJu, Republic of Korea

Received 22 May 2009 ,Revised 15 September 2009 ,Accepted 23 November 2009.

References 

  1. Jeong YY, Mitchell DG, Kamishima T. Small (<20mm) enhancing hepatic nodules seen on arterial phase MR imaging of the cirrhotic liver: clinical implications. AJR Am J Roentgenol. 2002;178:1327–1334
  2. Holland AE, Hecht EM, Hahn WY, et al. Importance of small (≤20-mm) enhancing lesions seen only during the hepatic arterial phase at MR imaging of the cirrhotic liver: evaluation and comparison with whole explanted liver. Radiology. 2005;237:938–944
  3. Kim YK, Lee YH, Kwak HS, et al. Clinical implication of small (<20mm) enhancing hepatic nodules observed only during three-dimensional gadobenate dimeglumine-enhanced hepatic arterial-phase MRI of the hepatitis B virus-induced mild cirrhosis. Clin Imaging. 2008;32:453–459
  4. Kim MJ, Kim JH, Chung JJ, et al. Focal hepatic lesions: detection and characterization with combination gadolinium- and superparamagnetic iron oxide-enhanced MR imaging. Radiology. 2003;228:719–726
  5. Ward J, Guthrie JA, Scott DJ, et al. Hepatocellular carcinoma in the cirrhotic liver: double-contrast MR imaging for diagnosis. Radiology. 2000;216:154–162
  6. Kim YK, Kwak HS, Han YM, et al. Usefulness of combining sequentially acquired gadobenate dimeglumine-enhanced magnetic resonance imaging and resovist-enhanced magnetic resonance imaging for the detection of hepatocellular carcinoma: comparison with computed tomography hepatic arteriography and computed tomography arterioportography using 16-slice multidetector computed tomography. J Comput Assist Tomogr. 2007;31:702–711
  7. Jung G, Breuer J, Poll LW, et al. Imaging characteristics of hepatocellular carcinoma using the hepatobiliary contrast agent Gd-EOB-DTPA. Acta Radiol. 2006;47:15–23
  8. Tanimoto A, Satoh Y, Yuasa Y, et al. Performance of Gd-EOB-DTPA and superparamagnetic iron oxide particles in the detection of primary liver cancer: a comparative study by alternative free-response receiver operating characteristic analysis. J Magn Reson Imaging. 1997;7:120–124
  9. Vogl TJ, Kummel S, Hammerstingl R, et al. Liver tumors: comparison of MR imaging with Gd-EOB-DTPA and Gd-DTPA. Radiology. 1996;200:59–67
  10. Halavaara J, Breuer J, Ayuso C, et al. Liver tumor characterization: comparison between liver-specific gadoxetic acid disodium-enhanced MRI and biphasic CT—a multicenter trial. J Comput Assist Tomogr. 2006;30:345–354
  11. Huppertz A, Haraida S, Kraus A, et al. Enhancement of focal liver lesions at gadoxetic acid-enhanced MR imaging: correlation with histopathologic findings and spiral CT — initial observations. Radiology. 2005;234:468–478
  12. Ward J, Robinson PJ. How to detect hepatocellular carcinoma in cirrhosis. Eur Radiol. 2002;12:2258–2272
  13. Pugh RN, Murray-Lyon IM, Dawson JL, et al. Transection of the esophagus for bleeding esophageal varices. Br J Surg. 1973;60:646–649
  14. Edmondson HA, Steiner PE. Primary carcinoma of liver: study of 100 cases among 48,900 necropsies. Cancer. 1954;7:462–503
  15. Lencioni R, Pinto F, Armillotta N, et al. Intrahepatic metastatic nodules of hepatocellular carcinoma detected at Lipiodol CT: imaging–pathologic correlation. Abdom Imaging. 1997;22:253–258
  16. Chakraborty DP, Winter LH. Free-response methodology: alternate analysis and a new observer-performance experiment. Radiology. 1990;74:873–881
  17. Metz CE. ROC methodology in radiologic imaging. Invest Radiol. 1986;21:720–733
  18. Rao JN, Scott AJ. A simple method for the analysis of clustered binary data. Biometrics. 1992;48:577–585
  19. Tanaka M, Nakashima O, Wada Y, et al. Pathomorphological study of Kupffer cells in hepatocellular carcinoma and hyperplastic nodular lesions in the liver. Hepatology. 1996;24:807–812
  20. Kim YK, Lee YH, Kwak HS, et al. Small malignant hepatic tumor detection in gadolinium- and ferucarbotran-enhanced magnetic resonance imaging: does combining ferucarbotran-enhanced T2*-weighted gradient echo and T2-weighted turbo spin echo images have additive efficacy?. Korean J Radiol. 2008;9:510–519
  21. Kim YK, Kim CS, Lee YH, et al. Comparison of superparamagnetic iron oxide-enhanced and gadobenate dimeglumine-enhanced dynamic MRI for detection of small hepatocellular carcinomas. AJR Am J Roentgenol. 2004;182:1217–1223
  22. Bartolozzi C, Crocetti L, Lencioni R, et al. Biliary and reticuloendothelial impairment in hepatocarcinogenesis: the diagnostic role of tissue-specific MR contrast media. Eur Radiol. 2007;17:2519–2530
  23. Bruix J, Sherman M, Practice Guidelines Committee , American Association for the Study of Liver Diseases . Management of hepatocellular carcinoma. Hepatology. 2005;42:1208–1236

PII: S0009-9260(10)00039-5

doi: 10.1016/j.crad.2009.11.012

Clinical Radiology
Volume 65, Issue 5 , Pages 358-365 , May 2010