Clinical Radiology
Volume 65, Issue 4 , Pages 302-307 , April 2010

Three-dimensional multivoxel spectroscopy of the healthy hippocampus—are the metabolic differences related to the location?

  • J. Ostojic

      Affiliations

    • Institute of Oncology Sremska Kamenica, Diagnostic Imaging Center, Institutski Put 4, 21204 Sremska Kamenica Republic of Serbia
    • Corresponding Author InformationGuarantor and correspondent. Tel.: +381 214805610; fax: +381 214805602.
  • ,
  • D. Kozic

      Affiliations

    • Institute of Oncology Sremska Kamenica, Diagnostic Imaging Center, Institutski Put 4, 21204 Sremska Kamenica Republic of Serbia
  • ,
  • J. Konstantinovic

      Affiliations

    • Institute of Oncology Sremska Kamenica, Diagnostic Imaging Center, Institutski Put 4, 21204 Sremska Kamenica Republic of Serbia
  • ,
  • N. Covickovic-Sternic

      Affiliations

    • Institute of Neurology, Clinical Center of Serbia, School of Medicine, University of Belgrade, Dr Subotića 6, 110000 Belgrade, Republic of Serbia
  • ,
  • M. Mijajlovic

      Affiliations

    • Institute of Neurology, Clinical Center of Serbia, School of Medicine, University of Belgrade, Dr Subotića 6, 110000 Belgrade, Republic of Serbia
  • ,
  • K. Koprivsek

      Affiliations

    • Institute of Oncology Sremska Kamenica, Diagnostic Imaging Center, Institutski Put 4, 21204 Sremska Kamenica Republic of Serbia
  • ,
  • R. Semnic

      Affiliations

    • Institute of Oncology Sremska Kamenica, Diagnostic Imaging Center, Institutski Put 4, 21204 Sremska Kamenica Republic of Serbia

Received 7 July 2009 ,Revised 31 October 2009 ,Accepted 8 November 2009.

References 

  1. De Leon M, Bobinski M, Convit A, et al. Studies of the Hippocampus in Normal Aging and in Alzheimer's Disease. New York, NY: Oxford University Press; 1999;698-714
  2. El Falogy H, Benuska J. History, anatomical nomenclature, comparative anatomy and functions of the hippocampal formation. Bratisl Lek Listy. 2006;107:103–106
  3. Zola Morgan SM, Squire LR. The primate hippocampal formation: evidence for a time-limited role in memory storage. Science. 1990;250:288–290
  4. Campbell S, Macqueen G. The role of the hippocampus in the pathophysiology of major depression. J Psychiatry neurosci. 2004;29:417–426
  5. Sala M, Perez J, Soloff P, et al. Stress and hippocampal abnormalities in psychiatric disorders. Eur Neuropsychopharmacol. 2004;14:393–405
  6. Suzuki WA, Amaral DG. Perirhinal and parahippocampal cortices of the macaque monkey: cortical afferents. J Comp Neurol. 1994;350:497–533
  7. Salmenperä T, Kälviäinen R, Partanen K, et al. MRI volumetry of the hippocampus, amygdale, entorhinal cortex, and perirhinal cortex after status epilepticus. Epilepsy Res. 2000;40:155–170
  8. Nelson MD, Saykin AJ, Flashman LA, et al. Hippocampal volume reduction in schizophrenia as assessed by MRI. Arch Gen Psychiatry. 1998;55:433–440
  9. Simic G, Kostovic I, Winblad B, et al. Volume and number of neurons of the human hippocampal formation in normal aging and Alzheimer's disease. J Comp Neurol. 1997;379:482–494
  10. Shin LM, Shin PS, Heckers S, et al. Hippocampal function in posttraumatic stress disorder. Hippocampus. 2004;14:292–300
  11. Urenjak J, Williams SR, Gadian DG, et al. Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types. J Neurosc. 1993;13:981
  12. Achten E, Santens P, Boon P, et al. Single-voxel proton MR spectroscopy and positron emission tomography for lateralization of refractory temporal lobe epilepsy. AJNR Am J Neuroradiol. 1998;19:1–8
  13. Mueller SG, Laxer KD, Barakos JA, et al. Identification of the epileptogenic lobe in neocortical epilepsy with proton MR spectroscopic imaging. Epilepsia. 2004;45:1580–1589
  14. Lee SK, Kim DW, Kim KK, et al. Effect of seizure on hippocampus in mesial temporal lobe epilepsy and neocortical epilepsy: an MRS study. Neuroradiology. 2005;47:916–923
  15. Chantal S, Braun CM, Bouchard RW, et al. Similar 1H magnetic resonance spectroscopic metabolic pattern in the medial temporal lobes of patients with mild cognitive impairment and Alzheimer disease. Brain Res. 2004;1003:26–35
  16. Deicken RF, Zhou L, Schuff N, et al. Hippocampal neuronal dysfunction in schizophrenia as measured by proton magnetic resonance spectroscopy. Biol Psychiatry. 1998;43:483–488
  17. Ham BJ, Chey J, Yoon SJ, et al. Decreased N-acetyl-aspartate levels in anterior cingulate and hippocampus in subjects with post-traumatic stress disorder: a proton magnetic resonance spectroscopy study. Eur J Neurosci. 2007;25:324–329
  18. Vermathen P, Laxer K, Matson G, et al. Hippocampal structures: anteroposterior N-acetylaspartate differences in patients with epilepsy and control subjects as shown with proton MR spectroscopic imaging. Radiology. 2000;214:403–410
  19. King K, Glodzik L, Songtao L, et al. Anteroposterior hippocampal metabolic heterogenity: three dimensional multivoxel proton 1H MR spectroscopic imaging—initial findings. Radiology. 2008;249:242–250
  20. Mouritzen Dam A. The density of neurons in the human hippocampus. Neuropathol Appl Neurobiol. 1979;5:249–264
  21. Moser MB, Moser EL. Functional differentiation in the hippocampus. Hippocampus. 2002;12:415–420
  22. Paller KA, McCarthy G. Field potentials in the human hippocampus during the encoding and recognition of visual stimuli. Hippocampus. 2002;12:415–420
  23. Greicius MD, Krasnow B, Boyett-Anderson JM, et al. Regional analysis of hippocampal activation during memory encoding and retrieval: fMRI study. Hippocampus. 2003;13:164–174
  24. Sa MJ, Ruela C, Madeira MD. Dendritic right/left asymmetries in the neurons of the human hippocampal formation: a quantitative golgi study. Arq Neuropsiquiatr. 2007;65:1105–1113

PII: S0009-9260(10)00020-6

doi: 10.1016/j.crad.2009.11.011

Clinical Radiology
Volume 65, Issue 4 , Pages 302-307 , April 2010