CT and MRI features of acinar cell carcinoma of the pancreas with pathological correlations

Hsu, M.-Y.; Pan, K.-T.; Chu, S.-Y.; Hung, C.-F.; Wu, R.-C.; Tseng, J.-H.

doi:10.1016/j.crad.2009.11.010

« Previous Next »Clinical Radiology
Volume 65, Issue 3 , Pages 223-229, March 2010

CT and MRI features of acinar cell carcinoma of the pancreas with pathological correlations

M.-Y. Hsu
- Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, College of Medicine and School of Medical Technology, Chang Gung University, Taoyuan, Taiwan
K.-T. Pan
- Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, College of Medicine and School of Medical Technology, Chang Gung University, Taoyuan, Taiwan
S.-Y. Chu
- Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, College of Medicine and School of Medical Technology, Chang Gung University, Taoyuan, Taiwan
C.-F. Hung
- Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, College of Medicine and School of Medical Technology, Chang Gung University, Taoyuan, Taiwan
R.-C. Wu
- Department of Pathology, Chang Gung Memorial Hospital at Linkou, College of Medicine and School of Medical Technology, Chang Gung University, Taoyuan, Taiwan
J.-H. Tseng
- Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, College of Medicine and School of Medical Technology, Chang Gung University, Taoyuan, Taiwan
- Guarantor and correspondent: J.-H. Tseng, Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, 5 Fuhsing Street, Kwei-Shan, Taoyuan, Taiwan. Tel.: +886 3 3281200x2575; fax: +886 3 3971936.

Received 1 July 2009; received in revised form 17 October 2009; accepted 4 November 2009.

Aim

To document the computed tomography (CT) and magnetic resonance imaging (MRI) features of acinar cell carcinoma of the pancreas and to correlate them with pathological findings to determine the unique imaging manifestations of this rare subtype tumour of the pancreas.

Materials and methods

From January 1986 to August 2008, six patients (five men and one woman, mean age 61.3 years) with histologically proven acinar cell carcinoma of the pancreas underwent CT (n=6) and MRI (n=4) examinations. The imaging features of each tumour were documented and compared with pathological findings.

Results

The tumours were distributed in the head (n=4), body (n=1), and tail (n=1) of the pancreas. Four masses (67%) were uniformly or partially well-defined with thin, enhancing capsules. Central cystic components were found in five tumours (83%). Two tumours (33%) exhibited intratumoural haemorrhage, and one tumour (17%) had amorphous intratumoural calcification. In both CT and MRI, the tumours enhanced less than the adjacent normal pancreatic parenchyma. The signal intensity on MRI was predominantly T1 hypointense and T2 iso- to hyperintense.