Clinical Radiology
Volume 64, Issue 12 , Pages 1166-1174 , December 2009

Can breast MRI computer-aided detection (CAD) improve radiologist accuracy for lesions detected at MRI screening and recommended for biopsy in a high-risk population?

  • T. Arazi-Kleinman

      Affiliations

    • Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada
    • Department of Medical Imaging Tel Aviv Sourasky Medical Centre, Sackler School of Medicine Tel Aviv University, Tel Aviv, Israel
    • Corresponding Author InformationGuarantor and correspondent: T. Arazi-Kleinman, Department of Medical Imaging, Tel Aviv Sourasky Medical Center, 6 Weitzman St, Tel Aviv 64239, Israel. Tel.: +972 3 697 3504; fax: +972 3 697 3077.
    • ,
  • P.A. Causer

      Affiliations

    • Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada
    • ,
  • R.A. Jong

      Affiliations

    • Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada
    • ,
  • K. Hill

      Affiliations

    • Division of Medical Oncology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada
    • ,
  • E. Warner

      Affiliations

    • Division of Medical Oncology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada

Received 18 April 2009 ,Revised 2 August 2009 ,Accepted 6 August 2009.

References 

  1. Morris EA. Breast cancer imaging with MRI. Radiol Clin North Am. 2002;40:443–466
  2. Heywang SH, Wolf A, Pruss E, et al. MR Imaging of the breast with Gd-DTPA: use and limitations. Radiology. 1989;171:95–103
  3. Kaiser WA, Zeitler E. MR Imaging of the breast: fast imaging sequences with and without Gd-DTPA. Preliminary observations. Radiology. 1989;170:681–686
  4. Kriege M, Brekelmans C, Boetes C, et al. Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition. N Engl J Med. 2004;351:427–437
  5. Kuhl CK, Schmutzler RK, Leutner CC, et al. Breast MR imaging screening in 192 women proved or suspected to be carriers of a breast cancer susceptibility gene: preliminary results. Radiology. 2000;215:267–279
  6. Tilanus-Linthorst MM, Obdeijn IM, Bartels KC, et al. First experiences in screening women at high risk for breast cancer. Breast Cancer Res Treat. 2000;63:53–60
  7. Warner E, Plewes DB, Shumak RS, et al. Comparison of breast magnetic resonance imaging, mammography and ultrasound for surveillance of women at high risk for hereditary breast cancer. J Clin Oncol. 2001;19:3524–3531
  8. Stoutjesdijk MJ, Boetes C, Jager GJ, et al. Magnetic resonance imaging and mammography in women with a hereditary risk of breast cancer. J Natl Cancer Inst. 2001;93:1095–1102
  9. Lehman CD, Peacock S, DeMartini WB, et al. A new automated software system to evaluate breast MR examinations: improved specificity without decreased sensitivity. AJR Am J Roentgenol. 2006;187:51–56
  10. DeMartini WB, Lehman CD, Peacock S, et al. Computer-aided detection applied to breast MRI: assessment of CAD-generated enhancement and tumor sizes in breast cancers before and after neoadjuvant chemotherapy. Acad Radiol. 2005;12:806–814
  11. Wood C. Computer aided detection (CAD) for breast MRI. Technol Cancer Res Treat. 2005;4:49–53
  12. Williams TC, DeMartini WB, Partridge SC, et al. Breast MR imaging: computer-aided evaluation program for discriminating benign from malignant lesions. Radiology. 2007;244:94–103
  13. Levman J, Leung T, Causer P, et al. Classification of dynamic contrast-enhanced magnetic resonance breast lesions by support vector machines. IEEE Trans Med Imaging. 2008;27:688–696
  14. Warner E, Plewes DB, Hill KA, et al. Surveillance of BRCA1 and BRCA2 mutation carriers with magnetic resonance imaging, ultrasound, mammography, and clinical breast examination. J Am Med Assoc. 2004;292:1317–1325
  15. Ikeda DM, Hylton NM, Kinkel K, et al. Development, standardization and testing of a lexicon for reporting contrast-enhanced breast magnetic resonance imaging studies. J Magn Reson Imaging. 2001;14:889–895
  16. Morris EA. Illustrated breast MRI lexicon. Semin Roentgenol. 2001;36:238–249
  17. American College of Radiology . BI-RADS: MRI. In: Breast imaging reporting and data system: BI-RADS atlas. 4th ed.. Reston, VA: American College of Radiology; 2003;
  18. American College of Radiology . BI-RADS: mammography. In: Illustrated breast imaging reporting and data system: BI-RADS. 3rd ed.. Reston, VA: American College of Radiology; 1998;
  19. Kuhl CK, Meilcareck P, Klaschik S, et al. Dynamic breast MR imaging: are signal intensity time course data useful for differential diagnosis of enhancing lesions?. Radiology. 1999;211:101–110
  20. SAS, Statistical Analysis Stystem, Version 8.2, 2002; SAS Institute Inc, Cary, NC, USA.
  21. Rosner B. Fundamentals of Biostatistics. Thomson Higher Education, Belmont CA, USA. 6th edition, 2006.
  22. Hintze JL. Number Cruncher Statistical System (NCSS). User's guide. V. Kaysville: Utah; 2003;pp. 5071–5078
  23. Orel SG, Shnall MD, LiVolsi VA, et al. Suspicious breast lesions: MR imaging with radiologic–pathologic correlation. Radiology. 1994;190:485–493
  24. Stomper PC, Herman S, Klippenstein DL, et al. Suspect breast lesions: finding at dynamic gadolinium-enhanced MR imaging correlated with mammography and pathologic features. Radiology. 1995;197:387–395
  25. Hamilton LJ, Evans AJ, Wilson ARM, et al. Breast imaging finding in women with BRCA-1 and BRCA-2 associated breast carcinoma. Clin Radiol. 2004;59:895–902
  26. Schnall MD, Blume J, Bluemke DA, et al. Diagnostic architectural and dynamic features at breast MR imaging: multicentric study. Radiology. 2006;238:42–53
  27. Han BK, Schnall MD, Orel SG, et al. Outcome of MRI guided breast biopsy. AJR Am J Roentgenol. 2008;191:1798–1804

☆ This research was presented at the RSNA 2007.

PII: S0009-9260(09)00281-5

doi: 10.1016/j.crad.2009.08.003

Clinical Radiology
Volume 64, Issue 12 , Pages 1166-1174 , December 2009

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