Computer-aided detection (CAD) as a second reader using perspective filet view at CT colonography: effect on performance of inexperienced readers

Fisichella, V.A.; Jäderling, F.; Horvath, S.; Stotzer, P.-O.; Kilander, A.; Båth, M.; Hellström, M.

doi:10.1016/j.crad.2009.05.012

« Previous Next »Clinical Radiology
Volume 64, Issue 10 , Pages 972-982, October 2009

Computer-aided detection (CAD) as a second reader using perspective filet view at CT colonography: effect on performance of inexperienced readers

V.A. Fisichella
- Department of Radiology, Sahlgrenska University Hospital and Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
- Guarantor and correspondent: V. Fisichella, Department of Radiology, Sahlgrenska University Hospital, Bruna Stråket 11, 41342 Gothenburg, Sweden. Tel.: +46 31 3427181; fax: +46 31 822995.
F. Jäderling
- Department of Radiology, St. Göran's Hospital, Stockholm, Sweden
S. Horvath
- Department of Radiology, Sahlgrenska University Hospital and Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
P.-O. Stotzer
- Department of Gastroenterology, Sahlgrenska University Hospital, Gothenburg, Sweden
A. Kilander
- Department of Gastroenterology, Sahlgrenska University Hospital, Gothenburg, Sweden
M. Båth
- Department of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg, Sweden
M. Hellström
- Department of Radiology, Sahlgrenska University Hospital and Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

Received 1 December 2008; received in revised form 27 April 2009; accepted 5 May 2009.

Aim

To evaluate whether computer-aided detection (CAD) as a second reader using perspective filet view [three-dimensional (3D) filet] improves the performance of inexperienced readers at computed tomography colonography (CTC) compared with unassisted 3D filet and unassisted two-dimensional (2D) CTC.

Material and methods

Fifty symptomatic patients underwent CTC and same-day colonoscopy with segmental unblinding. Two inexperienced readers read the CTC studies on 3D filet and 2D several weeks apart. Four months later, readers re-read the cases only evaluating CAD marks using 3D filet. Suspicious CAD marks not previously described on 3D filet were recorded. Jackknife free-response receiver operating characteristic (JAFROC-1) analysis was used to compare the observers' performances in detecting lesions with 3D filet, 2D and 3D filet with CAD.

Results

One hundred and three lesions ≥3mm were detected at colonoscopy with segmental unblinding. CAD alone had a sensitivity of 73% (75/103) at a mean false-positive rate per patient of 12.8 in supine and 11.4 in prone. For inexperienced readers sensitivities with 3D filet with CAD were 58% (60/103) and 48% (50/103) with an improvement of 14–16 percentage points (p<0.05) compared with 2D and of 10–11 percentage points (p<0.05) compared with 3D filet. For inexperienced readers, the false-positive rate was 25–41% and 71–200% higher with 3D filet with CAD compared with 3D filet and 2D, respectively. JAFROC-1 analysis showed no significant differences in per-lesion overall performance among reading modes (p=0.8).

Conclusion

CAD applied as a second reader using 3D filet increased both sensitivity and the number of false positives by inexperienced readers compared with 3D filet and 2D, thus not improving overall performance, i.e., the ability to distinguish between lesions and non-lesions.