Clinical Radiology
Volume 64, Issue 10 , Pages 1015-1025 , October 2009

Imaging of paediatric liver tumours with pathological correlation

  • C.J. Das

      Affiliations

    • Department of Radiodiagnosis, All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi, India
    • Corresponding Author InformationGuarantor and correspondent: C.J. Das, Department of Radiodiagnosis, All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi 110029, India. Tel.: +91 9868619810.
  • ,
  • S. Dhingra

      Affiliations

    • Department of Radiodiagnosis, All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi, India
  • ,
  • A.K. Gupta

      Affiliations

    • Department of Radiodiagnosis, All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi, India
  • ,
  • V. Iyer

      Affiliations

    • Department of Pathology, All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi, India
  • ,
  • S. Agarwala

      Affiliations

    • Department of Paediatric Surgery, All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi, India

Received 2 January 2009 ,Revised 26 April 2009 ,Accepted 28 April 2009.

References 

  1. Jha P, Chawla SC, Tavri S, et al. Pediatric liver tumors—a pictorial review. Eur Radiol. 2009;19:209–219
  2. Litten JB, Tomlinson GE. Liver tumors in children. Oncologist. 2008;13:812–820
  3. Willert JR, Dahl G. Hepatoblastoma. Available at: http://emedicine.medscape.com/article/986802-overview[accessed 19.04.09]
  4. Byrne JA, Simms LA, Little MH, et al. Three non-overlapping regions of chromosome arm 11p allele loss identified in infantile tumors of adrenal and liver. Genes Chromosomes Cancer. 1993;8:104–111
  5. Hughes LJ, Michels VV. Risk of hepatoblastoma in familial adenomatous polyposis. Am J Med Genet. 1992;43:1023–1025
  6. Han SJ, Yoo S, Choi SH, et al. Actual half life of alpha fetoprotein as a prognostic tool in pediatric malignant tumors. Pediatr Surg Int. 1997;12:599–602
  7. Weinberg AG, Finegold MJ. Primary hepatic tumors of childhood. Hum Pathol. 1983;14:512–537368
  8. Rugge M, Sonego F, Pollice L, et al. DNA nuclear content, proliferative indices, and pathology. Liver. 1998;18:128–133
  9. Exelby PR, Filler RM, Grosfeld JL. Liver tumors in children in the particular reference to hepatoblastoma and hepatocellular carcinoma: American Academy of Pediatrics Surgical Section Survey—1974. J Pediatr Surg. 1975;10:329–337
  10. Donnelly LF, Bisset GS. Pediatric hepatic imaging. Radiol Clin North Am. 1998;36:413–427
  11. Ni YH, Chang MH, Hsu HY, et al. Hepatocellular carcinoma in childhood. Clinical manifestations and prognosis. Cancer. 1991;68:1737–1741
  12. Tanaka S, Kitamura T, Fujita M, et al. Color Doppler flow imaging of liver tumors. AJR Am J Roentgenol. 1990;154:509–514
  13. Oto A, Tamm EP, Szklaruk J. Multidetector row CT of the liver. Radiol Clin North Am. 2005;43:827–848
  14. Martin DR, Danrad R, Hussain SM. MR imaging of the liver. Radiol Clin North Am. 2005;43:861–886
  15. Buetow PC, Midkiff RB. MR imaging of the liver. Primary malignant neoplasms in the adult. Magn Reson Imaging Clin N Am. 1997;5:289–318
  16. Kimura H, Nakajima T, Kagawa K, et al. Angiogenesis in hepatocellular carcinoma as evaluated by CD34 immunohistochemistry. Liver. 1998;18:14–19
  17. Nakanuma Y, Ohta G. Expression of Mallory bodies in hepatocellular carcinoma in man and its significance. Cancer. 1986;57:81–86
  18. Ichikawa T, Federle MP, Grazioli L, et al. Fibrolamellar hepatocellular carcinoma: imaging and pathologic findings in 31 recent cases. Radiology. 1999;213:352–361
  19. Orsatti G, Hytiroglou P, Thung SN, et al. Lamellar fibrosis in the fibrolamellar variant of hepatocellular carcinoma: a role for transforming growth factor beta. Liver. 1997;17:152–156
  20. Berman MA, Burnham JA, Sheahan DG. Fibrolamellar carcinoma of the liver: an immunohistochemical study of nineteen cases and a review of the literature. Hum Pathol. 1988;19:784–794
  21. Stocker JT, Ishak KG. Undifferentiated (embryonal) sarcoma of the liver: report of 31 cases. Cancer. 1978;42:336–348
  22. Lauwers GY, Grant LD, Donnelly WH, et al. Hepatic undifferentiated (embryonal) sarcoma arising in a mesenchymal hamartoma. Am J Surg Pathol. 1997;21:1248–1254
  23. Moon WK, Kim WS, Kim IO, et al. Undifferentiated embryonal sarcoma of the liver: US and CT findings. Pediatr Radiol. 1994;24:500–503
  24. Yoon W, Kim JK, Kang HK. Hepatic undifferentiated embryonal sarcoma: MR findings. J Comput Assist Tomogr. 1997;21:100–102
  25. Nicol K, Savell V, Moore J, et al. Distinguishing undifferentiated embryonal sarcoma of the liver from biliary tract rhabdomyosarcoma: a Children's Oncology Group study. Pediatr Dev Pathol. 2007;10:89–97
  26. Ros PR, Olmsted WW, Dachman AH, et al. Undifferentiated (embryonal) sarcoma of the liver: radiologic–pathologic correlation. Radiology. 1986;161:141–145
  27. Roebuck DJ, Yang WT, Lam WW, et al. Hepatobiliary rhabdomyosarcoma in children: diagnostic radiology. Pediatr Radiol. 1998;28:101–108
  28. Gerber MA, Thung SN, Bodenheimer HC, et al. Characteristic histologic triad in liver adjacent to metastatic neoplasm. Liver. 1986;6:85–88
  29. Selby DM, Stocker JT, Waclawiw MA, et al. Infantile hemangioendothelioma of the liver. Hepatology. 1994;20:39–45
  30. Dachman AH, Lichtenstein JE, Friedman AC, et al. Infantile hemangioendothelioma of the liver: a radiologic–pathologic–clinical correlation. AJR Am J Roentgenol. 1983;140:1091–1096
  31. Pobiel RS, Bisset GS. Pictorial essay: imaging of liver tumors in the infant and child. Pediatr Radiol. 1995;25:495–506
  32. Mortele KJ, Mergo PJ, Urrutia M. Dynamic gadolinium-enhanced MR findings in infantile hepatic hemangioendothelioma. J Comput Assist Tomogr. 1998;22:714–717
  33. Dehner LP, Ishak KG. Vascular tumors of the liver in infants and children. A study of 30 cases and review of the literature. Arch Pathol. 1971;92:101–111
  34. DeMaioribus CA, Lally KP, Sim K, et al. Mesenchymal hamartoma of the liver. A 35-year review. Arch Surg. 1990;125:598–600
  35. Hirata GI, Matsunaga ML, Medearis AL, et al. Ultrasonographic diagnosis of a fetal abdominal mass: case of a mesenchymal liver hamartoma and a review of the literature. Prenat Diagn. 1990;10:507–512
  36. Giyanani VL, Meyers PC, Wolfson JJ. Mesenchymal hamartoma of the liver: computed tomography and ultrasonography. J Comput Assist Tomogr. 1986;10:51–54
  37. Ros PR, Goodman ZD, Ishak KG, et al. Mesenchymal hamartoma of the liver: radiologic–pathologic correlation. Radiology. 1986;158:619–624
  38. Nord KM, Kandel J, Lefkowitch JH, et al. Multiple cutaneous infantile haemangiomas associated with hepatic angiosarcoma: case report and review of the literature. Pediatrics. 2006;118:e907–e913
  39. Mergo PJ, Ros PR. Benign lesions of the liver. Radiol Clin North Am. 1998;36:319–331
  40. Leslie DF, Johnson CD, Johnson CM, et al. Distinction between cavernous haemangiomas of the liver and hepatic metastases on CT: value of contrast enhancement patterns. AJR Am J Roentgenol. 1995;164:625–629
  41. McFarland EG, Mayo-Smith WW, Saini S, et al. Hepatic haemangiomas and malignant tumors: improved differentiation with heavily T2-weighted conventional spin-echo MR imaging. Radiology. 1994;193:43–47
  42. Tung GA, Cronan JJ. Percutaneous needle biopsy of hepatic cavernous hemangioma. J Clin Gastroenterol. 1993;16:117–122
  43. Caseiro-Alves F, Zins M, Mahfouz A-E, et al. Calcification in focal nodular hyperplasia: a new problem for differentiation from fibrolamellar hepatocellular carcinoma. Radiology. 1996;198:889–892
  44. Paulson EK, McClellan JS, Washington K, et al. Hepatic adenoma: MR characteristics and correlation with pathologic findings. AJR Am J Roentgenol. 1994;163:113–116
  45. Butron Vila MM, Haot J, Desmet VJ. Cholestatic features in focal nodular hyperplasia of the liver. Liver. 1984;4:387–395

PII: S0009-9260(09)00205-0

doi: 10.1016/j.crad.2009.04.014

Clinical Radiology
Volume 64, Issue 10 , Pages 1015-1025 , October 2009