Clinical Radiology
Volume 64, Issue 7 , Pages 724-733 , July 2009

Imaging of the gastrointestinal complications of systemic chemotherapy

  • C.G. Cronin

      Affiliations

    • Department of Radiology, University College Hospital, Galway, Ireland
    • Corresponding Author InformationGuarantor and correspondent: C. Cronin, Department of Radiology, University College Hospital, Galway, Ireland. Tel.: +353 91 544857; fax: +353 91 521197.
  • ,
  • M. O'Connor

      Affiliations

    • Department of Oncology, University College Hospital, Galway, Ireland
  • ,
  • D.G. Lohan

      Affiliations

    • Department of Radiology, University College Hospital, Galway, Ireland
  • ,
  • M. Keane

      Affiliations

    • Department of Oncology, University College Hospital, Galway, Ireland
  • ,
  • C. Roche

      Affiliations

    • Department of Radiology, University College Hospital, Galway, Ireland
  • ,
  • J.F. Bruzzi

      Affiliations

    • Department of Radiology, University College Hospital, Galway, Ireland
  • ,
  • J.M. Murphy

      Affiliations

    • Department of Radiology, University College Hospital, Galway, Ireland

Received 10 October 2008 ,Revised 21 January 2009 ,Accepted 5 February 2009.

References 

  1. Pear BL. Pneumatosis intestinalis: a review. Radiology. 1998;207:13–19
  2. Davila ML. Neutropenic enterocolitis. Curr Opin Gastroenterol. 2006;22:44–47
  3. Hortobagyi GN, Frye D, Buzdar AU, et al. Decreased cardiac toxicity of doxorubicin administered by continuous intravenous infusion in combination chemotherapy for metastatic breast carcinoma. Cancer. 1989;63:37–45
  4. Kennedy MJ, Zahurak ML, Donehower RC, et al. Phase I and pharmacologic study of sequences of paclitaxel and cyclophosphamide supported by granulocyte colony-stimulating factor in women with previously treated metastatic breast cancer. J Clin Oncol. 1996;14:783–791
  5. Fleming RA, Miller AA, Stewart CF. Etoposide: an update. Clin Pharm. 1989;8:274–293
  6. Dunton CJ. Management of treatment-related toxicity in advanced ovarian cancer. Oncologist. 2002;7:11–19
  7. D'Amato G, Lima CR, Mahany JJ, et al. Neutropenic enterocolitis (typhlitis) associated with docetaxel therapy in a patient with non-small-cell lung cancer: case report and review of literature. Lung Cancer. 2004;44:381–390
  8. Li Z, Ibrahim NK, Wathen JK, et al. Colitis in patients with breast carcinoma treated with taxane-based chemotherapy. Cancer. 2004;101:1508–1513
  9. Daniele B, Rossi GB, Losito S, et al. Ischaemic colitis associated with paclitaxel. J Clin Gastroenterol. 2001;33:159–160
  10. Resnik E, Lefevre CA. Fulminant Clostridium difficile colitis associated with paclitaxel and carboplatin chemotherapy. Int J Gynecol Cancer. 1999;9:512–514
  11. Seewaldt V, Cain JM, Greer BE, et al. Bowel complications with taxol therapy. J Clin Oncol. 1993;11:1198
  12. Keidan RD, Fanning J, Gatenby RA, et al. Recurrent typhlitis, a disease resulting from aggresive chemotherapy. Dis Colon Rectum. 1989;32:206–209
  13. Petalozzi BC, Sotos GA, Choyke PL, et al. Typhlitis resulting from treatment with Taxol and doxorubicin in patients with metastatic breast cancer. Cancer. 1993;71:1797–1800
  14. Epstein M, Chiu A, Medina P, et al. Typhlitis, clostridia septicum bacteraemia, and septic arthritis after treatment with paclitaxel and carboplatin in a patient with non-small cell lung cancer. Cancer Ther. 1998;1:174–177
  15. Rose PG, Piver MS. Intestinal perforation secondary to paclitaxel. Gynecol Oncol. 1995;57:270–272
  16. Feldman. Sleisenger & Fordtran's Gastrointestinal and Liver Disease, 8th ed. Chapter 120. 2006. Available at: http://phstwlp1.partners.org:2872/about/book/saunders.html.
  17. Kennedy BJ. 5-Fluorouracil toxicity. Cancer. 1999;86:1099–1100
  18. Gizzi G, Biasco G, Villani V, et al. Endoscopic evidence of GI haemorrhage induced by 5-fluorouracil administration. Gastrointest Endosc. 2003;57:785–787
  19. Ter RB, Infantolino A, Leite LP, et al. Gastrointestinal ulceration and haemorrhage from hepatic arterial infusion chemotherapy. Gastrointest Endosc. 1999;49:92
  20. Kelvin FM, Gramm HF, Gluck WL, et al. Radiologic manifestations of small-bowel toxicity due to floxuridine therapy. AJR Am J Roentgenol. 1986;146:39–43
  21. Saif MW, Elfiky A, Salem RR. Gastrointestinal perforation due to bevacizumab in colorectal cancer. Ann Surg Oncol. 2007;14:1860–1869
  22. Gray J, Murren J, Sharma A, et al. Perforated viscus in a patient with non-small cell lung cancer receiving bevacizumab. J Thorac Oncol. 2007;2:571–573
  23. Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004;350:2335–2342
  24. Demetri GD, von Mehren M, Blanke CD, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumours. N Engl J Med. 2002;347:472
  25. Heimann DM, Schwartzentruber DJ. Gastrointestinal perforations associated with interleukin-2 administration. J Immunother. 2004;27:254–258
  26. Furonaka M, Miyazaki M, Nakajima M, et al. Neutropenic enterocolitis in lung cancer: a report of two cases and a review of the literature. Intern Med. 2005;44:467–470
  27. Vlasveld LT, Zwaan FE, Fibbe WE, et al. Neutropenic enterocolitis following treatment with cytosine arabinoside-containing regimens for hematological malignancies: a potentiating role for amsacrine. Ann Hematol. 1991;62:129–134
  28. Tjon A, Tham RT, Vlasveld LT, et al. Gastrointestinal complications of cytosine-arabinoside chemotherapy: findings on plain abdominal radiographs. AJR Am J Roentgenol. 1990;154:95–98
  29. Jones GT, Abramson N. Gastrointestinal necrosis in acute leukemia: a complication of induction therapy. Cancer Invest. 1983;1:315–320
  30. Dincol D, Icli F, Erekul S, et al. Primary gastrointestinal lymphomas in Turkey: a retrospective analysis of clinical features and results of treatment. J Surg Oncol. 1992;51:270–273
  31. Haim N, Leviov M, Ben Arieh Y, et al. Intermediate and high-grade gastric non-Hodgkin's lymphoma: a prospective study of non-surgical treatment with primary chemotherapy, with or without radiotherapy. Leuk Lymphoma. 1995;17:321–326
  32. Toghill PJ, Burke JD. Death from paralytic ileus following vincristin therapy. Postgrad Med J. 1970;46:330–331
  33. Rosenberg RF, Caridi JD. Vincristin-induced megacolon. Gastrointest Radiol. 1983;8:71–73
  34. Büyükaşik Y, Ozcebe OI, Haznedaroğlu IC, et al. Neutropenic enterocolitis in adult leukemias. Int J Hematol. 1997;66:47–55
  35. Camera A, Andretta C, Villa MR, et al. Intestinal toxicity during induction chemotherapy with cytarabine-based regimens in adult acute myeloid leukemia. Hematol J. 2003;4:346–350
  36. Frick MP, Maile CW, Crass JR, et al. Computed tomography of neutropenic colitis. AJR Am J Roentgenol. 1984;143:763–765
  37. Kirkpatrick ID, Greenberg HM. Gastrointestinal complications in the neutropenic patient: characterization and differentiation with abdominal CT. Radiology. 2003;226:668–674
  38. Kirkpatrick IDC, Greenberg HM. Evaluating the CT diagnosis of Clostridium difficile colitis: should CT guide therapy?. AJR Am J Roentgenol. 2001;176:635–639
  39. Boland GW, Lee MJ, Cats AM, et al. Antibiotic-induced diarrhea: specificity of abdominal CT for the diagnosis of Clostridium difficile disease. Radiology. 1994;191:103–106
  40. Shamberger RC, Weinstein HJ, Delorey MJ, et al. The medical and surgical management of typhlitis in children with acute non-lymphocytic (myelogenous) leukemia. Cancer. 1986;57:603–609
  41. Philpotts LE, Heiken JP, Westcott MA, et al. Colitis: use of CT findings in differential diagnosis. Radiology. 1994;190:445–449
  42. Ash L, Baker ME, O'Malley CM, et al. Colonic abnormalities on CT in adult hospitalized patients with Clostridium difficile colitis: prevalence and significance of findings. AJR Am J Roentgenol. 2006;186:1393–1400
  43. Macari M, Balthazar EJ, Megibow AJ. The accordion sign on CT: a nonspecific finding in patients with colonic oedema. Radiology. 1999;211:743–746
  44. Talamonti MS, Dawes LG, Joehl RJ, et al. Gastrointestinal lymphoma. A case for primary surgical resection. Arch Surg. 1990;125:972–977
  45. Meyers PA, Potter V, Wollner N, et al. Bowel perforation during initial treatment for childhood non-Hodgkin's lymphoma. Cancer. 1985;56:259–261
  46. Liaw CC, Huang JS, Wang HM, et al. Spontaneous gastroduodenal perforation in patients with cancer receiving chemotherapy and steroids. Cancer. 2006;72:1382–1385
  47. Schwartzentruber D, Lotze MT, Rosenberg SA. Colonic perforation. An unusual complication of therapy with high-dose interleukin-2. Cancer. 1988;62:2350–2353
  48. Traina TA, Norton L, Drucker K, et al. Nasal septum perforation in a bevacizumab-treated patient with metastatic breast cancer. Oncologist. 2006;11:1070
  49. Nielsen GL, Sorensen HT, Mellemkjoer L, et al. Risk of hospitalization resulting from upper gastrointestinal bleeding among patients taking corticosteroids: a register-based cohort study. Am J Med. 2001;111:541–545
  50. Allerton R. Acute mesenteric ischemia associated with 5-FU, cisplatin, and vincristine chemotherapy. Clin Oncol. 1996;8:116–117
  51. Matolo NM, Garfinkle SE, Wolfman EF. Intestinal necrosis and perforation in patients receiving immunosuppressive drugs. Am J Surg. 1976;132:753–754
  52. Theodossiou C, Kroog G, Ettinghausen S. Acute arterial thrombosis in a patient with breast cancer after chemotherapy with 5-fluorouracil, doxorubicin, leucovorin, cyclophosphamide, and interleukin-3. Cancer. 1994;74:2808–2810
  53. Schmitt M, Kuhn W, Harbeck N. Thrombophylic state in breast cancer. Semin Thromb Hemost. 1999;25:157–166

PII: S0009-9260(09)00101-9

doi: 10.1016/j.crad.2009.02.016

Clinical Radiology
Volume 64, Issue 7 , Pages 724-733 , July 2009