Clinical Radiology
Volume 64, Issue 1 , Pages 1-11 , January 2009

Imaging patients with myeloma

  • A.P. Winterbottom
  • ,
  • A.S. Shaw

      Affiliations

    • Corresponding Author InformationGuarantor and correspondent: A.S. Shaw, Box 218, Department of Radiology, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK. Tel.: +44 1223 216516; fax: +44 1223 217847.

Received 7 April 2008 ,Revised 7 July 2008 ,Accepted 15 July 2008.

References 

  1. Cancer Research UK . UK multiple myeloma incidence statistics. <http://info.cancerresearchuk.org/cancerstats/types/multiplemyeloma/incidence/>[accessed 20.11.07]
  2. D'Sa S, Abilgaard N, Tighe T, et al. Guidelines for the use of imaging in the management of myeloma. Br J Haematol. 2007;137:49–63
  3. Smith A, Wisloff F, Samson D. Guidelines on the diagnosis and management of multiple myeloma 2005. Br J Haematol. 2005;132:410–451
  4. Angtuaco EJC, Fassas ABT, Walker R, et al. Multiple myeloma: clinical review and diagnostic imaging. Radiology. 2004;231:11–23
  5. Damaj G, Mohty M, Vey N, et al. Features of extramedullary and extraosseous multiple myeloma: a report of 19 patients from a single centre. Eur J Haematol. 2004;73:402–406
  6. Durie BGM, Salmon SE. A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. Cancer. 1975;36:842–854
  7. Durie BG, Kyle RA, Belch A, et al. Myeloma management guidelines: a consensus report from the scientific advisors of the international myeloma foundation. Hematol J. 2003;4:379–398
  8. Greipp PR, San Miguel J, Durie BGM, et al. International staging system for multiple myeloma. J Clin Oncol. 2005;23:3412–3420
  9. Ong F, Hermans J, Noordijk EM, et al. Is the Durie and Salmon diagnostic classification system for plasma cell dyscrasias still the best choice? Application of three classification systems on a large population-based registry on paraproteinaemia and multiple myeloma. Ann Hematol. 1995;70:19–24
  10. Collins CD. Review multiple myeloma. Cancer Imaging. 2004;4:S47–S53
  11. Sorenson SM. Multiple myeloma. <http://www.emedecine.com/Radio/topic460.htm>[accessed 07.12.07]
  12. Snapper I, Khan A. Myelomatosis: fundamentals and clinical features. Baltimore: University Park Press; 1971;
  13. Edelstyn GA, Gillespie PJ, Grebbell FS. The radiological demonstration of osseous metastases: experimental observations. Clin Radiol. 1967;18:158–162
  14. Mulligan ME. Skeletal abnormalities in multiple myeloma. Radiology. 2005;234
  15. Lecouvet FE, Malghem J, Michaux L, et al. Skeletal survey in advanced multiple myeloma: radiographic versus MR imaging survey. Br J Haematol. 1999;106:35–39
  16. Hart D, Wall BF. Radiation exposure of the UK population from medical and dental x-ray examinations. Didcot: National Radiological Protection Board; 2002;
  17. Kröpil P, Fenk R, Fritz LB, et al. Comparison of whole-body 64-slice multidetector computed tomography and conventional radiography in staging of multiple myeloma. Eur Radiol. 2008;18:51–58
  18. Ricci C, Cova M, Kang YS, et al. Normal age-related patterns of cellular and fatty bone marrow distribution in the axial skeleton: MR imaging study. Radiology. 1990;177:83–88
  19. Dimopoulos MA, Moulopoulos LA, Datseris I, et al. Imaging of myeloma bone disease. Acta Oncol. 2000;39:823–827
  20. Lecouvet FE, Vande Berg BC, Malghem J, et al. Magnetic resonance and computed tomography imaging in multiple myeloma. Semin Musculoskelet Radiol. 2001;5:43–55
  21. Moulopoulos LA, Varma DG, Dimopoulos MA. Multiple myeloma: spinal MR imaging in patients with untreated newly diagnosed disease. Radiology. 1992;185:833–840
  22. Libshitz HI, Malthouse SR, Cunningham D, et al. Multiple myeloma: appearance at MR imaging. Radiology. 1992;182:833–837
  23. Ghanem N, Lohrmann C, Engelhardt M, et al. Whole-body MRI in the detection of bone marrow infiltration in patients with plasma cell neoplasms in comparison to the radiological skeletal survey. Eur Radiol. 2006;16:1005–1014
  24. Baur-Melnyk A, Buhmann S, Wieser A, et al. MSCT versus MR imaging: diagnostic sensitivity in the detection of spine metastases. Eur Radiol. 2005;15(Suppl. 1):B-464
  25. Moulopoulos LA, Dimopoulos MA, Weber D, et al. Magnetic resonance imaging in the staging of solitary plasmacytoma of bone. J Clin Oncol. 1993;11:1311–1315
  26. Fonti R, Salvatore B, Quarantelli M, et al. 18F-FDG PET/CT, 99mTc-MIBI, and MRI in evaluation of patients with multiple myeloma. J Nucl Med. 2008;49:195–200
  27. Joffe J, Williams MP, Cherryman GR, et al. Magnetic resonance imaging in myeloma. Lancet. 1988;1:1162–1163
  28. Ludwig H, Kupman W, Sinzinger H. Radiography and bone scintigraphy in multiple myeloma: a comparative analysis. Br J Radiol. 1982;55:173–181
  29. Bataille R, Chevalier J, Rossi M, et al. Bone scintigraphy in plasma cell myeloma. A prospective study of 70 patients. Radiology. 1982;145:801–804
  30. Chae MJ, Lee TH, Park GY, et al. Comparing 18F-FDG-PET/CT with other imaging modalities for detecting involving bone of multiple myeloma. J Nucl Med. 2007;48(Suppl. 2):351
  31. Dankerl A, Liebisch P, Glatting G, et al. Multiple myeloma: molecular imaging with 11C-methionine PET/CT—initial experience. Radiology. 2007;242:498–508
  32. Bredella MA, Steinbach L, Caputo G, et al. Value of FDG PET in the assessment of patients with multiple myeloma. AJR Am J Roentgenol. 2005;184:1199–1204
  33. Sezer O, Niemöller K, Jakob C, et al. Relationship between bone marrow angiogenesis and plasma cell infiltration and serum beta 2 microglobulin levels in patients with multiple myeloma. Ann Haematol. 2001;80:598–601
  34. Wisloff F, Andersen P, Andersson TR, et al. Incidence and follow-up of asymptomatic multiple myeloma. The myeloma project of health region I in Norway II. Eur J Haematol. 1991;47:338–341
  35. Dimopoulos MA, Moulopoulos A, Smith T, et al. Risk of disease progression in asymptomatic multiple myeloma. Am J Med. 1993;94:57–61
  36. Weber DM. Prognostic features of asymptomatic multiple myeloma. Br J Haematol. 1997;97:810–814
  37. Mariette X, Zagdanski AM, Guermazi A, et al. Prognostic value of vertebral lesions detected by magnetic resonance imaging in patients with stage I multiple myeloma. Br J Haematol. 1999;104:723–729
  38. Stabler A, Baur A, Bartl R, et al. Contrast enhancement and quantitative signal analysis in MR imaging of multiple myeloma: assessment of focal and diffuse growth patterns in marrow correlated with biopsies and survival rates. AJR Am J Roentgenol. 1996;167:1029–1036
  39. Lecouvet FE, Vande Berg BC, Michaux L, et al. Stage III multiple myeloma: clinical and prognostic value of spinal bone marrow MR imaging. Radiology. 1998;209:653–660
  40. Moulopoulos LA, Gika D, Anagnostopoulos A, et al. Prognostic significance of magnetic resonance imaging of bone marrow in previously untreated patients with multiple myeloma. Ann Oncol. 2005;16:1824–1828
  41. Van de Berg BC, Lecouvet FE, Michaux L, et al. Stage I multiple myeloma: value of MR imaging of the bone marrow in the determination of prognosis. Radiology. 1996;201:243–246
  42. Soutar R, Lucraft H, Jackson G, et al. Guidelines on the diagnosis and management of solitary plasmacytoma of bone and solitary extramedullary plasmacytoma. Br J Haematol. 2004;124:717–726
  43. Lecouvet FE, Malghem J, Michaux L, et al. Vertebral compression fractures in multiple myeloma. Part II. Assessment of fracture risk with MR imaging of spinal bone marrow. Radiology. 1997;204:201–205
  44. Durie BG, Waxman AD, D'Agnolo A, et al. Whole-body (18)F-FDG PET identifies high-risk myeloma. J Nucl Med. 2002;43:1457–1463
  45. Mirels H. Metastatic disease in long bones. A proposed scoring system for diagnosing impending pathologic fractures. Clin Orthop. 1989;256–264
  46. Lecouvet FE, Vande Berg BC, Maldague BE, et al. Vertebral compression fractures in multiple myeloma. Part I. Distribution and appearance at MR imaging. Radiology. 1997;204:195–199
  47. Percutaneous vertebroplasty. National Institute for Clinical Excellence. <http://www.nice.org.uk/nicemedia/pdf/IPG12A4Updated.pdf> [accessed 03.12.07].
  48. Balloon kyphoplasty for vertebral compression fractures. National Institute for Clinical Excellence. <http://www.nice.org.uk/nicemedia/pdf/IPG166A4Updated.pdf> [accessed 03.1.07].
  49. Woo E, Yu YL, Ng M, et al. Spinal cord compression in multiple myeloma: who gets it?. Aust N Z J Med. 1986;16:671–675
  50. Speiss JL, Adelstein DJ, Hines F. Multiple myeloma presenting with spinal cord compression. Oncology. 1988;45:88–92
  51. Pazianas M, Miller P, Blumentals WA, et al. A review of the literature on osteonecrosis of the jaw in patients with osteoporosis treated with oral bisphosphonates: prevalence, risk factors, and clinical characteristics. Clin Ther. 2007;29:1548–1558
  52. European Group for Blood and Marrow transplantation (EBMT) , International Bone Marrow Transplant Registry (IBMTR) , Autologous Blood and Marrow Transplant Registry (ABMTR) . Criteria for evaluating disease response and progression inpatients with multiple myeloma treated by high-dose therapy and haematopoietic stem cell transplantation. Br J Haematol. 1998;102:1115–1123
  53. Moulopoulos LA, Dimopoulos MA, Alexanian R, et al. Multiple myeloma: MR patterns of response to treatment. Radiology. 1994;193:441–446
  54. Fruehwald FX, Tscholakoff D, Schwaighofer B, et al. Magnetic resonance imaging of the lower vertebral column in patients with multiple myeloma. Invest Radiol. 1988;23:193–199
  55. Baur-Melnyk A, Buhmann S, Dürr HR, et al. Role of MRI in the diagnosis and prognosis of multiple myeloma. Eur J Radiol. 2005;55:56–63
  56. Rahmouni A, Divine M, Mathieu D, et al. Detection of multiple myeloma involving the spine: efficacy of fat-suppression and contrast-enhanced MR imaging. AJR Am J Roentgenol. 1993;160:1049–1052

PII: S0009-9260(08)00293-6

doi: 10.1016/j.crad.2008.07.006

Clinical Radiology
Volume 64, Issue 1 , Pages 1-11 , January 2009