Clinical Radiology
Volume 63, Issue 1 , Pages 71-77 , January 2008

Biphosphonate-induced osteonecrosis of the jaws: CT and MRI spectrum of findings in 32 patients

  • S. Bisdas

      Affiliations

    • Department of Diagnostic and Interventional Radiology, Johann Wolfgang Goethe University Hospital, Frankfurt, Germany
    • Corresponding Author InformationGuarantor and correspondent: S. Bisdas, Department of Diagnostic and Interventional Radiology, Johann Wolfgang Goethe University Hospital, Theodor Stern Kai 7, D-60590 Frankfurt, Germany. Tel.: +49 69 6301 7292; fax: +49 69 6301 5252.
    • ,
  • N. Chambron Pinho

      Affiliations

    • Department of Dentomaxillofacial and Plastic Surgery, Johann Wolfgang Goethe University Hospital, Frankfurt, Germany
    • ,
  • A. Smolarz

      Affiliations

    • Department of Dentomaxillofacial and Plastic Surgery, Johann Wolfgang Goethe University Hospital, Frankfurt, Germany
    • ,
  • R. Sader

      Affiliations

    • Department of Dentomaxillofacial and Plastic Surgery, Johann Wolfgang Goethe University Hospital, Frankfurt, Germany
    • ,
  • T.J. Vogl

      Affiliations

    • Department of Diagnostic and Interventional Radiology, Johann Wolfgang Goethe University Hospital, Frankfurt, Germany
    • ,
  • M.G. Mack

      Affiliations

    • Department of Diagnostic and Interventional Radiology, Johann Wolfgang Goethe University Hospital, Frankfurt, Germany

Received 11 December 2006 ,Revised 11 April 2007 ,Accepted 23 April 2007.

References 

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  2. Ross JR, Saunders Y, Edmonds PM, et al. A systematic review of the role of bisphonates in metastatic disease. Health Technol Assess. 2004;8:1–176
  3. Conte P, Guarneri V. Safety of intravenous and oral biphosphonates and compliance with dosing regimens. Oncologist. 2004;9(Suppl. 4):28–37
  4. Badros A, Weikel D, Salama A, et al. Osteonecrosis of the jaw in multiple myeloma patients: clinical features and risk factors. J Clin Oncol. 2006;24:945–952
  5. Hansen T, Kunkel M, Weber A, et al. Osteonecrosis of the jaws in patients treated with biphosphonates–histomorphologic analysis in comparison with infected osteoradionecrosis. J Oral Pathol Med. 2006;35:155–160
  6. Farrugia MC, Summerlin DJ, Krowiak E, et al. Osteonecrosis of the mandible or maxilla associated with the use of new generation biphosphonates. Laryngoscope. 2006;116:115–120
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  8. Rogers MJ. New insights into the molecular mechanisms of action of biphosphonates. Curr Pharm Des. 2003;9:2643–2658
  9. Greenberg MS. Intravenous bisphosphonates and osteonecrosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;98:259–260
  10. Hishberg A, Leibovich P, Buchner A. Metastatic tumors to the jawbones: an analysis of 390 cases. J Oral Pathol Med. 1994;23:337–341
  11. Weber AL, Kaneda T, Scrivani SJ, et al. Jaw: cysts, tumors, and nontumorous lesions. In:  Som PM,  Curtin HD editor. Head and neck imaging. St Louis: Mosby; 2003;p. 930–995
  12. Unger E, Moldofsky P, Gatenby R, et al. Diagnosis of osteomyelitis by MR imaging. AJR Am J Roentgenol. 1988;150:605–610
  13. Chong J, Hinckley LK, Ginsberg LE. Masticator space abnormalities associated with mandibular osteoradionecrosis: MR and CT findings in five patients. AJNR Am J Neuroradiol. 2000;21:175–178
  14. Bouquot JE, Roberts AM, Person P, et al. Neuralgia-inducing cavitational osteonecrosis (NICO): osteomyelitis in 224 jawbone samples from patients with facial neuralgia. Oral Surg Oral Med Oral Pathol. 1992;73:307–309
  15. Carneiro E, Vibhute P, Montazem A, et al. Biphosphonate-associated mandibular osteonecrosis. AJNR Am J Neuroradiol. 2006;27:1096–1097
  16. Wang J, Godger NM, Pogrel MA. Osteonecrosis of the jaws associated with cancer chemotherapy. J Oral Maxillofac Surg. 2003;61:1104–1107
  17. Ruggiero SL, Mehotra MBBS, Rosenberg TJ, et al. Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases. J Oral Maxillofac Surg. 2004;62:527–534
  18. Chiandussi S, Biasotto M, Dore F, et al. Clinical and diagnostic imaging of bisphosphonate-associated osteonecrosis of the jaws. Dentomaxillofac Radiol. 2006;35:236–243

PII: S0009-9260(07)00321-2

doi: 10.1016/j.crad.2007.04.023

Clinical Radiology
Volume 63, Issue 1 , Pages 71-77 , January 2008

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