Lung lesion doubling times: values and variability based on method of volume determination

Quint, Leslie Eisenbud; Cheng, Joan; Schipper, Matthew; Chang, Andrew C.; Kalemkerian, Gregory

doi:10.1016/j.crad.2007.07.011

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Volume 63, Issue 1 , Pages 41-48, January 2008

Lung lesion doubling times: values and variability based on method of volume determination

Leslie Eisenbud Quint
- Department of Radiology, University of Michigan Health System, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0030, USA
- Guarantor and correspondent: Leslie Eisenbud Quint, MD, Professor of Radiology, University of Michigan Health System, Department of Radiology, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0030, USA. Tel.: +1 734 936 8871; fax: +1 734 615 1276.
Joan Cheng
- Department of Radiology, University of Michigan Health System, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0030, USA
Matthew Schipper
- Department of Radiology, University of Michigan Health System, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0030, USA
Andrew C. Chang
- Department of Surgery, University of Michigan Health System, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0030, USA
Gregory Kalemkerian
- Department of Internal Medicine, University of Michigan Health System, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0030, USA

Received 6 December 2006; received in revised form 10 July 2007; accepted 21 July 2007.

Purpose

To determine doubling times (DTs) of lung lesions based on volumetric measurements from thin-section CT imaging.

Methods

Previously untreated patients with ≥ two thin-section CT scans showing a focal lung lesion were identified. Lesion volumes were derived using direct volume measurements and volume calculations based on lesion area and diameter. Growth rates (GRs) were compared by tissue diagnosis and measurement technique.

Results

54 lesions were evaluated including 8 benign lesions, 10 metastases, 3 lymphomas, 15 adenocarcinomas, 11 squamous carcinomas, and 7 miscellaneous lung cancers. Using direct volume measurements, median DTs were 453, 111, 15, 181, 139 and 137 days, respectively. Lung cancer DTs ranged from 23–2239 days. There were no significant differences in GRs among the different lesion types. There was considerable variability among GRs using different volume determination methods.