Clinical Radiology
Volume 62, Issue 6 , Pages 528-538, June 2007

The radiological manifestations of sickle cell disease

  • G. Madani

      Affiliations

    • Department of Radiology, Royal Free Hospital NHS Trust, London, UK
    • Corresponding Author InformationGuarantor and correspondent: G. Madani, Department of Radiology, Royal Free Hospital NHS Trust, Pond Street, London NW3 2QG, UK. Tel.: +44 20 7794 0500x1467.
    • ,
  • A.M. Papadopoulou

      Affiliations

    • Department of Radiology, Royal Free Hospital NHS Trust, London, UK
    • ,
  • B. Holloway

      Affiliations

    • Department of Radiology, Royal Free Hospital NHS Trust, London, UK
    • ,
  • A. Robins

      Affiliations

    • Department of Paediatrics, Whittington Hospital NHS Trust, London, UK
    • ,
  • J. Davis

      Affiliations

    • Department of Radiology, Whittington Hospital NHS Trust, London, UK
    • ,
  • D. Murray

      Affiliations

    • Department of Radiology, Whittington Hospital NHS Trust, London, UK

Received 7 July 2006; received in revised form 20 December 2006; accepted 2 January 2007.

Sickle cell disease (SCD) is an inherited abnormality of the ß-globin chain, which causes a spectrum of haemolytic anaemias. Clinical manifestations in SCD include anaemia, jaundice, recurrent vaso-occlusive crises, and infections (particularly by encapsulated bacteria) due to functional asplenia and cerebrovascular accidents. Radiological investigations play a critical role both in the diagnosis and in the primary prevention of the complications of SCD.

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PII: S0009-9260(07)00035-9

doi:10.1016/j.crad.2007.01.006

Clinical Radiology
Volume 62, Issue 6 , Pages 528-538, June 2007

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