Clinical Radiology
Volume 61, Issue 9 , Pages 771-775, September 2006

Diagnostic accuracy of CT-guided percutaneous cutting needle biopsy for thymic tumours

  • K. Yonemori

      Affiliations

    • Divisions of Diagnostic Radiology
    • Corresponding Author InformationGuarantor and correspondent: K. Yonemori, Division of Diagnostic Radiology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. Tel.:+81 3 3542 2511; fax: +81 3 3542 3815.
    • ,
  • K. Tsuta

      Affiliations

    • Diagnostic Pathology
    • ,
  • U. Tateishi

      Affiliations

    • Divisions of Diagnostic Radiology
    • ,
  • H. Uno

      Affiliations

    • Division of Biostatistics, Kitasato University Graduate School, Minato-ku, Tokyo, Japan
    • ,
  • H. Asamura

      Affiliations

    • Thoracic Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo
    • ,
  • Y. Matsuno

      Affiliations

    • Diagnostic Pathology
    • ,
  • M. Kusumoto

      Affiliations

    • Divisions of Diagnostic Radiology

Received 14 November 2005; received in revised form 6 April 2006; accepted 21 April 2006.

Aim

To determine the diagnostic accuracy of computed tomography (CT)-guided percutaneous cutting needle biopsy (PCNB) for thymic tumours in accordance with the World Health Organization (WHO) classification.

Material and methods

We retrospectively analysed a consecutive series of 138 cases in which CT-guided PCNB had been performed for an anterior mediastinal tumour. Its sensitivity and specificity for thymic epithelial tumours were evaluated, and the concordance between the histopathological diagnosis according to the WHO classification of thymic tumours based on PCNB and the diagnosis is based on the surgical specimens was assessed by Kappa statistic.

Results

The diagnostic sensitivity and specificity of CT-guided PCNB for thymic tumours were 93.3 and 100%, respectively. The overall concordance between the diagnosis according to the WHO classification established by PCNB specimen and by the surgical specimen was 79.4% (weighted kappa=0.79).

Conclusion

CT-guided PCNB is a reliable method of diagnosing thymic tumours, and there was good concordance for the WHO classification between the diagnosis based on CT-guided PCNB specimen and that based on the surgical specimen.

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PII: S0009-9260(06)00142-5

doi:10.1016/j.crad.2006.04.011

Clinical Radiology
Volume 61, Issue 9 , Pages 771-775, September 2006

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